Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks.
نویسندگان
چکیده
A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
منابع مشابه
Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes.
Desferrioxamine (DFO) and the hydroxypiridinone (HPO) deferiprone (CP20) chelate iron as well as other metals. These chelators are used clinically to treat iron overload, but they induce apoptosis in thymocytes. Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators may induce apoptosis by depleting stores of zinc. Exposure of murine thymocytes to either DFO...
متن کاملRED CELLS Cellular zinc content is a major determinant of iron chelator–induced apoptosis of thymocytes
Desferrioxamine (DFO) and the hydroxypiridinone (HPO) deferiprone (CP20) chelate iron as well as other metals. These chelators are used clinically to treat iron overload, but they induce apoptosis in thymocytes. Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators may induce apoptosis by depleting stores of zinc. Exposure of murine thymocytes to either DFO...
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 96 شماره
صفحات -
تاریخ انتشار 2013